Modeling Cardiac Arrhythmias With Organoids

Frequency of Cardiac Arrhythmias in Patients with Aluminum Phosphide Poisoning

Background: Cardiac failure is the major lethal consequence of aluminum phosphide (AlP) poisoning. This study was designed to determine the frequency of cardiac arrhythmias in patients with AlP poisoning. Methods: In this prospective cross-sectional study, patients with definitive history of AlP poisoning treated at emergency department of Allied Hospital Faisalabad, Faisalabad, Pakistan, from ...

Modeling Circadian Rhythmicity of Cardiac Arrhythmias

The cardiomyocyte circadian (~24-hour) clock influences multiple intracellular processes, including transcription and contractile function, and has recently been linked to ventricular arrhythmias in mice [1]. Circadian rhythms have also been observed in transient outward potassium current (Ito), a current that dominates mice action potential (AP) repolarization. We used mathematical modeling to...

Modeling Development and Disease with Organoids

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Add...

Kidney organoids for disease modeling

Cardiac arrhythmias.

Disorders of cardiac rate and rhythm represent major causes of mortality and morbidity in developed countries. Sudden cardiac death, defined as death within 1 hour of an unexpected change in cardiovascular status, kills more than 300,000 people each year in the United States (29), whereas nonlethal arrhythmias account for much additional disability. Atrial fibrillation, a leading cause of cereb...